7  Objectives

To compare the capacity of different MIPD approaches to predict (first) dose to obtain target concentrations of 40-80 mg.\(L^{-1}\) based on the patient’s covariates.

8 Judgement criteria

The proportion of subjects whose predicted dose allows for obtaining concentrations in the target interval of 40-80 mg.\(L^{-1}\) (target interval is based on the guidelines of SFPT - the French Society of Pharmacology and Therapeutics Guilhaumou et al. (2019)). For patients, whose extrapolated dose to reach 40 mg/L was higher than 20 g, the ability to predict the fact that the dose is above 20 g was evaluated.

9 Context

Numerous MIPD approaches have already been developed to predict a posteriori concentrations. Application of the a priori approaches developed in this project could help certain patients to reach target concentrations interval faster this way improving clinical results and to reduce the number of necessary blood samples.

Guilhaumou, Romain, Sihem Benaboud, Youssef Bennis, Claire Dahyot-Fizelier, Eric Dailly, Peggy Gandia, Sylvain Goutelle, et al. 2019. “Optimization of the Treatment with Beta-Lactam Antibiotics in Critically Ill Patients-Guidelines from the French Society of Pharmacology and Therapeutics (Société Française de Pharmacologie Et Thérapeutique-SFPT) and the French Society of Anaesthesia and Intensive Care Medicine (Société Française d’anesthésie Et Réanimation-SFAR).” Crit. Care 23 (1): 104.